In Greek mythology, Alcimede (//; Ancient Greek: Ἀλκιμέδη means 'mighty cunning') was one of the matrilineal Minyan daughters, the daughter of Clymene, Minyas' daughter. She was the mother of Jason by Aeson, King of Iolcus.  She met Aeson in the caves below Iolcus in Thessaly, a chthonic lair where the rightful king Aeson had been imprisoned by his evil half-brother Pelias. In some accounts, Alcimede was called the daughter of Autolycus; the same was said of Polymele, another possible mother of Jason.
A hint of matrilineal descent in archaic times among the Boeotian Minyans of Greece is in Apollonius' aside concerning Jason's heritage:
- "So many then were the helpers who assembled to join the son of Aeson. All the chiefs the dwellers thereabout called Minyae, for the most and the bravest avowed that they were sprung from the blood of the daughters of Minyas; thus Jason himself was the son of Alcimede, who was born of Clymene, the daughter of Minyas."
A further hint of archaic matrilineal descent is that Clymene's consort is offered in two versions: she was usually cast as the wife of Phylacus (son of Deioneus, son of Aeolus) or in some versions, Aeson was fathered by Cephalus, otherwise the consort of Procris.
- Apollonius Rhodius, Argonautica translated by Robert Cooper Seaton (1853-1915), R. C. Loeb Classical Library Volume 001. London, William Heinemann Ltd, 1912. Online version at the Topos Text Project.
- Apollonius Rhodius, Argonautica. George W. Mooney. London. Longmans, Green. 1912. Greek text available at the Perseus Digital Library.
- Gaius Julius Hyginus, Fabulae from The Myths of Hyginus translated and edited by Mary Grant. University of Kansas Publications in Humanistic Studies. Online version at the Topos Text Project.
- Gaius Valerius Flaccus, Argonautica translated by Mozley, J H. Loeb Classical Library Volume 286. Cambridge, MA, Harvard University Press; London, William Heinemann Ltd. 1928. Online version at theio.com.
- Gaius Valerius Flaccus, Argonauticon. Otto Kramer. Leipzig. Teubner. 1913. Latin text available at the Perseus Digital Library.
- Pausanias, Description of Greece with an English Translation by W.H.S. Jones, Litt.D., and H.A. Ormerod, M.A., in 4 Volumes. Cambridge, MA, Harvard University Press; London, William Heinemann Ltd. 1918. Online version at the Perseus Digital Library
- Pausanias, Graeciae Descriptio. 3 vols. Leipzig, Teubner. 1903. Greek text available at the Perseus Digital Library.